618-620 Cortez LAJP 1429

نویسندگان

  • Daniele F. FELIPE
  • Benedito P. DIAS FILHO
  • Celso V. NAKAMURA
چکیده

The antimicrobial activity of different extracts of Piper regnellii was evaluated through the broth microdilution assay. The leaves, roots and stems extracts presented a good activity against Staphylococcus aureus and Bacillus subtilis with minimal inhibitory concentration (MIC) between 31.25 62.5 μg/ml. Although the differences were not significant, the leaves hydroalcoholic extract tended to be more active than the stems and roots extracts. In the anti yeast assay, all extracts of P. regnellii displayed good activity against Candida tropicalis (MIC = 62.5 μg/ml) and a moderate response against Candida albicans (MIC = 250 μg/ml). The results indicate that the vegetal specie P. regnellii demonstrate promising antimicrobial activity and could be used as raw material by pharmaceutical industry. RESUMO. “Avaliação da atividade antimicrobiana de Piper regnellii (Miq.) C. DC. var. pallescens (C. DC.) Yunck”. A atividade antimicrobiana de diferentes extratos de Piper regnellii foi avaliada pelo método de microdiluição. Extratos das folhas, raízes e caules apresentaram uma boa atividade em Staphylococcus aureus e Bacillus subtilis com uma concentração inibitória mínima (CIM) entre 31.25 62.5 μg/ml. Diferenças significativas não foram encontradas, o extrato hidroalcoólico das folhas mostrou-se mais ativos do que os extratos do caule e raízes. A atividade antifúngica dos extratos de P. regnellii mostrou-se uma boa atividade em Candida tropicalis (CIM = 62.5 μg/ml) e moderada em Candida albicans (CIM = 250 μg/ml). Estes resultados indicam que a espécie vegetal P. regnellii demosntrou uma promissora atividade antimicrobiana e poderá ser utilizado como uma matéria prima vegetal pela indústria farmacêutica.

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تاریخ انتشار 2008